β-Peptides as inhibitors of protein–protein interactions
نویسندگان
چکیده
منابع مشابه
b-Peptides as inhibitors of protein–protein interactions
We became interested several years ago in exploring whether 14-helical b-peptide foldamers could bind protein surfaces and inhibit protein–protein interactions, and if so, whether their affinities and specificities would compare favorably with those of natural or miniature proteins. This exploration was complicated initially by the absence of a suitable b-peptide scaffold, one that possessed a ...
متن کاملbeta-Peptides as inhibitors of protein-protein interactions.
We became interested several years ago in exploring whether 14-helical beta-peptide foldamers could bind protein surfaces and inhibit protein-protein interactions, and if so, whether their affinities and specificities would compare favorably with those of natural or miniature proteins. This exploration was complicated initially by the absence of a suitable beta-peptide scaffold, one that posses...
متن کاملBioengineered Peptides Based on α1-PDX Structure as Inhibitors of Furin: Design, Synthesis and Comparative Efficacy
Furin is a Ca 2+ <span style="color: #231f20; font-family: Times New...
متن کاملNatural peptides and proteins: potent tyrosinase inhibitors
Background and objectives: Tyrosinase is a copper containing oxidase which is crucial for controlling the production of melanin in creatures such as bacteria, fungi, plants and mammals. It is involved in the first two steps of melanin biosynthesis and leads to pigmentation and different types of cancer such as melanoma. Also, it is responsible for browning of fruits and vegetab...
متن کاملShort Peptides as Inhibitors of Amyloid Aggregation
The misfolding and aggregation of proteins into amyloid has been linked to a variety of age-related diseases. Aggregation of proteins, such as Aβ in Alzheimer's disease and Islet Amyloid Polypeptide (IAPP, amylin) in type 2 diabetes, appears to lead to the formation of toxic assemblies. These assemblies range in size from small oligomers (2-8 proteins) to large fibrils (thousands of proteins). ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2005
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2004.09.009